Any chance you are changing the screens pretty much right before you shut the car off? I find that if I make screen changes and then drive around some, they are more likely to still be there the next time I get in the car. But, if I do stuff right before shutting the car off, they are sometimes not saved. This could be "luck", but it's my current working theory.
Found same; Make changes before you go on a drive. Everything in profiles seem to 'stick' if you do it in that order.